90Y-DOTA-biotin

90Y-DOTA-biotin
A compound that contains the radioisotope yttrium Y 90 linked to the chemical biotin. Biotin is a molecule that binds strongly to the chemical streptavidin. 90Y-DOTA-biotin will find tumor cells in the body that have been targeted by an antibody linked to streptavidin and kill them. It is being studied together with CC49-streptavidin in the treatment of cancer.
Also called yttrium Y 90 DOTA-biotin.

English dictionary of cancer terms . 2015.

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  • 90Y-DOTA-biotin — consists of a radioactive substance (yttrium 90) complexed by a chelating agent (DOTA), which in turn is attached to the vitamin biotin via a chemical linker. It is used experimentally in pretargeted radioimmunotherapy. Animal studies have been… …   Wikipedia

  • 90Y-DOTA-biotin — noun The vitamin biotin labelled with radioactive (yttrium 90); it is used in the treatment of cancer where it seeks out tumor cells that have been targeted by an antibody linked to strepavidin and kill them …   Wiktionary

  • yttrium Y 90 DOTA-biotin — A compound that contains the radioisotope yttrium Y 90 linked to the chemical biotin. Biotin is a molecule that binds strongly to the chemical streptavidin. Yttrium Y 90 DOTA biotin will find tumor cells in the body that have been targeted by an… …   English dictionary of cancer terms

  • DOTA (chelator) — DOTA IUPAC name 1,4,7,10 tetraazacyclododecane 1,4,7,10 tetraacetic acid …   Wikipedia

  • List of oncology-related terms — This is a list of terms related to oncology. The original source for this list was the U.S. National Cancer Institute s public domain Dictionary of Cancer Terms . NOTOC 1 * 10 propargyl 10 deazaaminopterin * 12 O tetradecanoylphorbol 13 acetate * …   Wikipedia

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