phase I trial

phase I trial
The first step in testing a new treatment in humans. These studies test the best way to give a new treatment (for example, by mouth, intravenous infusion, or injection) and the best dose. The dose is usually increased a little at a time in order to find the highest dose that does not cause harmful side effects. Because little is known about the possible risks and benefits of the treatments being tested, phase I trials usually include only a small number of patients who have not been helped by other treatments.

English dictionary of cancer terms . 2015.

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  • phase I trial — a clinical trial on normal volunteers, designed to determine the biological activities and range of toxicity or other safety factors of a given therapy …   Medical dictionary

  • phase II trial — a clinical trial on a small group of patients, designed to determine the effectiveness of the given regimen in treating the disorder in question …   Medical dictionary

  • phase III trial — a clinical trial that uses a large sample of patients and is designed to compare the overall course of their disorder under the new treatment with its course untreated and treated with standard therapies previously used; studies are also done on… …   Medical dictionary

  • phase IV trial — additional studies done after a drug has been approved for distribution or marketing, which could include examination of long term effects, adverse effects, or specific aspects of a drug s action …   Medical dictionary

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  • Phase 1 — may refer to:* Phase I Environmental Site Assessment * Phase 1 clinical trial * Phase 1 (bar)Phase One may also refer to:* Phase One The Danish camera equipment company …   Wikipedia

  • Phase I — may refer to: *Phase I of a clinical trial in medicine *Phase I Environmental Site Assessment *Phase I reactions in metabolismSee also: Phase (disambiguation) …   Wikipedia

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